The maximum amount of ibuprofen in 24 hours is 3200 mg. Children and infants can usually take ibuprofen every six to eight hours but should not have more than four doses in 24 hours unless directed by a doctor. If you are unsure about how much. Common Questions and Answers about Maximum ibuprofen dosage in 24 hours ibuprofen This problem of mine has occured maybe 5-7 times so far over a 3 year period, over which I'd estimate I've ingested about 20,000mg of ibuprofen (estimated about 150 small pills in a baggie in which I grabbed from when in need, 150mg each). Adults and teenagers—400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Do not take more than 8 pills in 24 hours Aspirin dosage daily limit is 4,000 mg Get your dose and frequency right to decrease your risk of harmful side effects You have at least 2 genuine conditions that require pain meds and you have never been early before.Perhaps ibuprofen 400mg 2 every 4 hours max 3200mg/24 hrs for a few days only will help somewhat.I really feel for you having all those autoimmune diseases at once.Just take the ibuprofen at that high dose for a very short time because of blood pressure. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form). Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Been popping two pills (200 mg each) every four hours after spraining my back. I just took the third dose. And I will take two more first thing in the morning. What is the daily limit for Ibuprofen? I'm trying to find out if there is a recommended dosage limit per 24 hours for Ibuprofen as there is for Tylenol, to lessen the possibility of hepatic compromise.